Friday, September 18, 2026

Advice for Young Scientists

I’m so worried about the state of American science. The layoffs in government research centers, the budget cutbacks, the difficulty of getting grants, the demonization of scientists, and the denial of entire branches of knowledge such as climate change and vaccines... it’s just terrible. I’m especially concerned about young scientists. The ones just starting out, trying to establish a career. It must be devastating for many.

Today I want to share some stories about another difficult time for young scientists, the mid 1990s. President Clinton was cutting federal funding for scientific research to try and balance the budget, scientists and engineers from the former Soviet Union and Eastern Europe were flooding the US job market, and former industry scientists were looking for jobs as centers like Bell Labs were cutting basic research. I don’t want to imply that 1995 was as bad as 2026, but there were some parallels.

I worked at the National Institutes of Health in Bethesda, Maryland in the late 1980s and early 1990s. I loved NIH, and believed that it was the greatest biomedical research institution anywhere, ever. I was in the Biomedical Engineering and Instrumentation Program (BEIP), which hired physicists, engineers, and mathematicians to collaborate with NIH biologists and medical doctors. BEIP wasn’t funded directly from Congress, but instead was a service organization that was supported by a “tax” on the other institutes.

When the cutbacks began in the mid 1990s, I was just about ready to be put up for a permanent position. BEIP didn’t hire “tenure-track” faculty like the institutes did. It did, however, have a tradition of deciding after six years if a staff fellow like me would be promoted into a permanent position, in a process similar to a tenure decision at at a university. Suddenly around 1994, we in BEIP who had been expecting to go up for a permanent spot started being called “postdocs” and were told we needed more “mentoring.” A month or two later we were told there was a hiring freeze and no BEIP staff fellows would be moved into permanent positions. I started looking for another job.

I applied to colleges and universities throughout the country. I searched for industrial positions too, and as time went by I even began looking for jobs at community colleges. I had no luck for months. Between April 1994 and September 1995 I received over one hundred rejection letters, and many more potential employers didn’t even bother to respond at all to my application. I began to worry how I was going to feed my two children. I had seven job interviews, but only two offers. One was verbal and informal (“we can make this happen if you are interested”) and the other (which I accepted) was for a non-tenure track Assistant Professorship at Vanderbilt University, where I had been a graduate student seven years earlier.

I wasn’t the only one in this situation. BEIP had four young researchers coming up for a decision about a permanent position, and we all were in the same boat. Let me tell you about the four of us. Perhaps our stories will provide hope to young people today facing the current job market. 

 

Akram Aldroubi

Akram Aldroubi (PhD, Carnegie Mellon 1987) was a mathematician who worked with the BEIP director, Murray Eden. He, Eden and Michael Unser published a series of highly cited papers about signal processing, investigating topics like b-splines and wavelets. In 1997 Akram moved to the Department of Mathematics at Vanderbilt University (he and I were reunited at Vanderbilt for a year until I left in 1998). He was coauthor with Peter Basser (more on Basser later) on a landmark paper about using MRI diffusion tensor imaging to do fiber tractography. Akram is still at Vanderbilt today, and in 2014 he was inducted as a fellow in the American Mathematical Society for his “contributions to modern harmonic analysis and its applications, and for building bridges between mathematics and other areas of science and engineering.” 

Akram Aldroubi 

https://www.youtube.com/watch?v=sn4GNGnFovY

 

Cynthia Sung

Cynthia Sung (PhD, Harvard-MIT, 1988) was in the Chemical Engineering Section of BEIP. There she worked with Robert Dedrick and Paul Morrison to study pharmacokinetics. After she left NIH she held a variety of positions, such as with the Gates Medical Research Institute and with the Food and Drug Administration. Cynthia went to Singapore and established her own consulting firm, Rainbow Pharma Consulting, and worked with the Singapore Health Sciences Authority. She’s now an Adjunct Associate Professor in the Centre of Regulatory Excellence at Duke-National University of Singapore Medical School. In 2023 she won the Titan Award for Community Collaboration to recognize her collaborative spirit in helping fellow community members reach their goals. 


Cynthia Sung 

https://www.youtube.com/watch?v=tlHEmLr_DTk

 

Joe Schmitt

Joe Schmitt (PhD, Stanford, 1986) worked in the Electrical Engineering Section of BEIP with Robert Bonner, studying how light propagates through tissue. After leaving NIH he was an Associate Professor in the Department of Electrical and Electronic Engineering at the Hong Kong University of Science and Technology. There he wrote a highly cited review about Optical Coherence Tomography (a topic discussed in Chapter 14 of Intermediate Physics for Medicine and Biology). He then entered industry and is now the Chief Technology Officer of LightLab Imaging

Joe Schmitt

https://www.youtube.com/watch?v=HqEuxXHW7Cs

 

Brad Roth

My PhD was from Vanderbilt in 1987. At NIH I worked for Seth Goldstein in the Mechanical Engineering Section of BEIP, the same section where my friend Peter Basser (the inventor of MRI diffusion tensor imaging) also worked. Basser was a year ahead of me, and he obtained a permanent position at NIH just before the hiring freeze took effect. After leaving NIH, I went back to Vanderbilt for three years, and then took a tenure-track faculty position at Oakland University in Rochester, Michigan, where I taught and did research for over two decades. One of my main accomplishments at OU was to become coauthor with Russell Hobbie on the textbook Intermediate Physics for Medicine and Biology. Though I was never again quite as productive as during those wonderful years at NIH, I nevertheless had a happy and successful career at Oakland. 


 Brad Roth

https://www.youtube.com/watch?v=IKjab7_unRA


Those are the stories of four young researchers who faced a rough patch in their careers just a little over 30 years ago. Fortunately, we all survived—and eventually thrived—in our lives after NIH, whether in academia, industry, or government. I know what young scientists face now is so much worse than what we encountered, and I don’t want to minimize their challenges. But we four friends did overcome our obstacles and managed to remain in science, making a living and contributing to knowledge. Our paths were sometimes tortuous, but with perseverance and patience—and a resurgence of science funding in the late 1990s—we managed to stay in the game. I hope you young scientists facing obstacles now (obstacles that are unfair and no fault of your own) can likewise find a way to stay in science and keep contributing. One thing I know for sure: our country needs you now more than ever.

Good luck. Have courage. Have hope.

Friday, September 11, 2026

The Page Proofs are Here!!!

The cover of the fifth edition of Intermediate Physics for Medicine and Biology.
The page proofs for the sixth edition of Intermediate Physics for Medicine and Biology have arrived, and they’ve taken over my life. I’ve got no time for much of anything else, including writing blog posts. My coauthor Gene Surdutovich and I are trying hard to fix all the errors, but man oh man is there a lot to check. The pdf of the proofs has about 580 pages, whereas the 5th edition had more like 650 (from title page to end of the index). So the book is down about 7% in number of pages. That’s good, because we cut out a lot of what we rarely teach in our classes. That decrease is even more impressive when you consider that we added a chapter on surface tension, we added a chapter on damage from ionizing radiation, and we split the chapter on feedback and nonlinear dynamics into two. In addition, readers now have over 1000 homework problems to test their understanding. So, really, we cut at least 10% from the chapter text present in the fifth edition.

That’s all for now, but just let me add a big thank you to all the readers of Intermediate Physics for Medicine and Biology. And let me assure you traditionalists out there that there’s still a lot of Russ Hobbie here in the sixth edition. It’s still his book, and he’s still first author.

Friday, September 4, 2026

Leon Glass and the Wandering Thoughts Podcast

From Clocks to Chaos, superimposed on the cover of Intermediate Physics for Medicine and Biology.
From Clocks to Chaos,
by Glass and Mackey.

Chapter 10 of Intermediate Physics for Medicine and Biology talks about nonlinear dynamics, and in particular how simple sets of nonlinear differential equations can lead to chaotic behavior. One researcher who Russ Hobbie and I mention often is Leon Glass. We cite his book with Michael Mackey, From Clocks to Chaos, which influenced me as a young scientist, and his textbook with Daniel KaplanUnderstanding Nonlinear Dynamics.

Recently I discovered a wonderful interview with Glass where he describes his life and work. It’s part of a podcast series titled Wandering Thoughts, and you can listen to it below. It’s over two hours long, but Glass talks slowly and I could understand it at 2× speed or even faster. It’s well worth the time.

Several topics covered in the interview will be interesting to readers of IPMB and of this blog. I’ve always been interested in how physicists end up learning and studying biology, and conversely how biologists learn physics. Right at the start of the interview Glass outlines his own circuitous path toward biological physics. Everyone has their own unique path, but Glass’s highlights one feature I find common in many: it isn’t part of a grand master plan, but just sort of happens, and is catalyzed by interactions with other scientists. Glass describes his work on the periodic electrical stimulation of chick heart cells, which Russ and I illustrate using a figure from one of his papers (in IPMB, it’s Fig. 10.36). Stimulation can simply drive the system in a 1:1 behavior, or give a more complicated periodic behavior at a lower frequency, or produce deterministic chaos. This is lovely work and Glass was one of the pioneers. He also talks about the modeling of spiral waves as an example of a heart arrhythmia, a concept studied by his friend and collegue Art Winfree. (In 2013 Glass won the Arthur T. Winfree Prize awarded by the Society of Mathematical Biology.) When asked what traits were most valuable to him in his career, Glass mentioned curiosity and tenacity. Those two traits would be useful to anyone wanting to learn biological physics from IPMB.  

This podcast provides insight into what a career in biological physics is like. Enjoy! 

Chaos in Biological Systems, with Leon Glass, on The Wandering Thoughts podcast.

https://music.youtube.com/watch?v=aDx9t2vA9s0